She studied art at Louisiana State University and Sophie Newcomb College. In 1925 at the LSU Art Department, she began working with the renowned muralist Conrad Albrizio, who encouraged her to explore and experiment, an attitude that Sachse retained throughout her 70-year painting career.
Although she did not adhere to any one technique or subject matter, Sachse most often painted the people and places of Louisiana, even traveling along the state’s newly built interstate in the early 1970s to create a series of paintings that detailed the landscape. She exhibited widely in Louisiana and was represented by Helen Seger’s La Boetie Gallery on New York’s Upper East Side.